Besides that we're low on lithium here on Earth, cosmologists are aware that the whole universe has less than it "should".
Couple articles are explaining that. First, the Big Bang nucleosynthesis as actually simulated turns out not to produce the amount of 7Li as the initial models had claimed. Since then, present classical novae - like recent V5669 Sgr - sometimes don't produce as much as, say, V339 Del.
Aristotle was right. Mathematical theory is all well and good, but no substitute for experiment and observation (respectively). Time to rethink those equations.
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